The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours
in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive …

Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …

The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …

The MTT assay (to a less degree MTS, XTT or WST) is a widely exploited approach for
measuring cell viability/drug cytotoxicity. MTT reduction occurs throughout a cell and can be …

Bone undergoes continuous remodeling, which is homeostatically regulated by concerted
communication between bone-forming osteoblasts and bone-degrading osteoclasts …

The specificities of 65 compounds reported to be relatively specific inhibitors of protein
kinases have been profiled against a panel of 70–80 protein kinases. On the basis of this …

Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …

The kinase pathway comprising RAS, RAF, mitogen-activated protein kinase kinase (MEK)
and extracellular signal regulated kinase (ERK) is activated in most human tumours, often …

The Ras/Raf/MEK/ERK signaling cascade that integrates an extreme variety of extracellular
stimuli into key biological responses controlling cell proliferation, differentiation or death is …