Tissue-specific parameters for the design of ECM-mimetic biomaterials
The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …
biochemically directs cell behavior and is crucial for maintaining tissue function and health …
Structural mechanisms in soft fibrous tissues: a review
M Sharabi - Frontiers in Materials, 2022 - frontiersin.org
Through years of evolution, biological soft fibrous tissues have developed remarkable
functional properties, unique hierarchical architectures, and-most notably, an unparalleled …
functional properties, unique hierarchical architectures, and-most notably, an unparalleled …
Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves
EL Johnson, DW Laurence, F Xu, CE Crisp… - Computer methods in …, 2021 - Elsevier
Approximately 1.6 million patients in the United States are affected by tricuspid valve
regurgitation, which occurs when the tricuspid valve does not close properly to prevent …
regurgitation, which occurs when the tricuspid valve does not close properly to prevent …
[HTML][HTML] A strategy of functional crosslinking acellular matrix in blood-contacting implantable devices with recombinant humanized collagen type III (rhCOLIII)
A large number of blood contacting implantable devices are used worldwide annually.
Acellular matrix (AM), as one of the blood-contacting materials, has achieved a great …
Acellular matrix (AM), as one of the blood-contacting materials, has achieved a great …
Mechanics of the tricuspid valve—From clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling
Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …
Integration of polarized spatial frequency domain imaging (pSFDI) with a biaxial mechanical testing system for quantification of load-dependent collagen architecture …
Collagen fiber networks provide the structural strength of tissues, such as tendons, skin and
arteries. Quantifying the fiber architecture in response to mechanical loads is essential …
arteries. Quantifying the fiber architecture in response to mechanical loads is essential …
The tricuspid valve also maladapts as shown in sheep with biventricular heart failure
Over 1.6 million Americans suffer from significant tricuspid valve leakage. In most cases this
leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve …
leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve …
Effects of enzyme-based removal of collagen and elastin constituents on the biaxial mechanical responses of porcine atrioventricular heart valve anterior leaflets
The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of
blood through a coordination of the extracellular matrix components, including the collagen …
blood through a coordination of the extracellular matrix components, including the collagen …
Study of biaxial mechanical properties of the passive pig heart: material characterisation and categorisation of regional differences
F Nemavhola - International Journal of Mechanical and Materials …, 2021 - Springer
Regional mechanics of the heart is vital in the development of accurate computational
models for the pursuit of relevant therapies. Challenges related to heart dysfunctioning are …
models for the pursuit of relevant therapies. Challenges related to heart dysfunctioning are …
[HTML][HTML] Biomechanics of mitral valve leaflets: Second harmonic generation microscopy, biaxial mechanical tests and tissue modeling
Collagen fibers are the main load carrier in the mitral valve (MV) leaflets. Their orientation
and dispersion are an important factor for the mechanical behavior. Most recent studies of …
and dispersion are an important factor for the mechanical behavior. Most recent studies of …