[HTML][HTML] The untapped potential of ascites in ovarian cancer research and treatment

CE Ford, B Werner, NF Hacker, K Warton - British journal of cancer, 2020 - nature.com
The build-up of fluid in the peritoneal cavity—ascites—is a hallmark of ovarian cancer, the
most lethal of all gynaecological malignancies. This remarkable fluid, which contains a …

[HTML][HTML] Spheroid formation and peritoneal metastasis in ovarian cancer: the role of stromal and immune components

M Rakina, A Kazakova, A Villert, L Kolomiets… - International journal of …, 2022 - mdpi.com
Ovarian cancer (OC) is one of the most common gynecological cancers, with the worst
prognosis and the highest mortality rate. Peritoneal dissemination (or carcinomatosis) …

The high-grade serous ovarian cancer metastasis and chemoresistance in 3D models

V Tadić, W Zhang, A Brozovic - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
High-grade serous ovarian cancer (HGSOC) is the most frequent and aggressive type of
epithelial ovarian cancer, with high recurrence rate and chemoresistance being the main …

[HTML][HTML] Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics

SA Pinho, SI Anjo, T Cunha-Oliveira - Antioxidants, 2023 - mdpi.com
Theragnostics is a promising approach that integrates diagnostics and therapeutics into a
single personalized strategy. To conduct effective theragnostic studies, it is essential to …

[HTML][HTML] Gene expression in organoids: an expanding horizon

A Smirnov, G Melino, E Candi - Biology Direct, 2023 - Springer
Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …

[HTML][HTML] In vitro models of ovarian cancer: bridging the gap between pathophysiology and mechanistic models

E Lopez, S Kamboj, C Chen, Z Wang, S Kellouche… - Biomolecules, 2023 - mdpi.com
Ovarian cancer (OC) is a disease of major concern with a survival rate of about 40% at five
years. This is attributed to the lack of visible and reliable symptoms during the onset of the …

Chemoresistance in ovarian cancer: the role of Malignant ascites

M Nunes, S Ricardo - Exon Publications, 2022 - exonpublications.com
Ascites is an inflammatory process that induces the abnormal accumulation of a large
amount of fluid into the peritoneal cavity. This pathological condition is observed in many …

[HTML][HTML] 3D tumor spheroid and organoid to model tumor microenvironment for cancer immunotherapy

Y Zhu, E Kang, M Wilson, T Basso, E Chen, Y Yu, YR Li - Organoids, 2022 - mdpi.com
The intricate microenvironment in which malignant cells reside is essential for the
progression of tumor growth. Both the physical and biochemical features of the tumor …

[HTML][HTML] Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells

R El Baba, S Haidar Ahmad, F Monnien, R Mansar… - Oncogene, 2023 - nature.com
Human cytomegalovirus (HCMV) infection has been implicated in epithelial ovarian cancer
(OC). Polyploidy giant cancer cells (PGCCs) have been observed in high-grade serous …

Multifaceted Cancer Alleviation by Cowpea Mosaic Virus in a Bioprinted Ovarian Cancer Peritoneal Spheroid Model

Y Xiang, Z Zhao, EJ Yao, A Balayan, SN Fiering… - Biomaterials, 2024 - Elsevier
Ovarian cancer (OvCa) is a leading cause of mortality among gynecological malignancies
and usually manifests as intraperitoneal spheroids that generate metastases, ascites, and …