Theca cells function in a diverse range of necessary roles during folliculogenesis; to
synthesize androgens, provide crosstalk with granulosa cells and oocytes during …

The maturation of ovarian follicles involves several sequential stages: initiation, growth,
selection, ovulation, and luteinization (Fig. 1). Although the factor (s) that initiates the growth …

Recent theories propose that a Western lifestyle may increase cancer risk through
alterations in the metabolism of insulin and insulin-like growth factors (IGF; McKeown …

I. History and Terminology: From Stein-Leventhal toFunctional Ovarian Hyperandrogenism
(FOH) IN 1935, Stein and Leventhal (1) reported the association of polycystic ovaries in …

Breast cancer incidence rates are high in societies with a Western lifestyle characterized by
low levels of physical activity, and by an energy-dense diet rich in total and saturated fat and …

The role of cytochrome P450 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase in the
integration of gonadal and adrenal steroidogenesis via the delta 5 and delta 4 pathways of …

The objective of the present study was to determine the effects of IGF-I and insulin on cell
proliferation, LH receptors, and basal and LH-induced progesterone and androstenedione …

Amino acids modulate the secretion of both insulin and glucagon; the composition of dietary
protein therefore has the potential to influence the balance of glucagon and insulin activity …

Insulin resistance, defined as a diminished effect of a given dose of insulin on glucose
homeostasis, is a highly prevalent feature of women with PCOS. Insulin resistance in PCOS …

The hyperandrogenism of polycystic ovary syndrome (PCOS) appears to be due to
dysregulation of steroidogenesis within the ovaries and adrenal glands. P450c17 is the key …