Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …

Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …

The mammalian hematopoietic system is remarkably efficient in meeting an organism's vital
needs, yet is highly sensitive and exquisitely regulated. Much of the organismal control over …

Trabecular bone maintains physiological homeostasis and consistent structure and mass
through repeated cycles of bone remodeling by means of tightly localized regulation. The …

Abstract Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for
3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC …

Microphysiological systems (MPSs) with three-dimensional (3D) cultured models have
attracted considerable interest because of their potential to mimic human health and disease …

Bone is one of the key components of the musculoskeletal system. Bone and joint disease
are the fourth most widespread disease, in addition to cardiovascular disease, cancer, and …

Cardiac organoids are 3-dimensional (3D) structures composed of tissue or niche-specific
cells, obtained from diverse sources, encapsulated in either a naturally derived or synthetic …

New drug modalities offer life-saving benefits for patients through access to previously
undruggable targets. Yet these modalities pose a challenge for the pharmaceutical industry …

Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …