Immune regulation by 4‐1BB and 4‐1BBL: complexities and challenges
C Wang, GHY Lin, AJ McPherson… - Immunological …, 2009 - Wiley Online Library
The tumor necrosis factor receptor family member 4‐1BB plays a key role in the survival of
activated and memory CD8+ T cells. Depending on the disease model, 4‐1BB can …
activated and memory CD8+ T cells. Depending on the disease model, 4‐1BB can …
CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction
Z Shao, H Schwarz - Journal of leukocyte biology, 2011 - academic.oup.com
ABSTRACT CD137 (4-1BB, TNFR superfamily 9) and its ligand are members of the TNFR
and TNF families, respectively, and are involved in the regulation of a wide range of immune …
and TNF families, respectively, and are involved in the regulation of a wide range of immune …
TCR-or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses
R Lamichhane, M Schneider, SM de la Harpe… - Cell reports, 2019 - cell.com
Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …
CD137 promotes proliferation and survival of human B cells
X Zhang, CJ Voskens, M Sallin, A Maniar… - The journal of …, 2010 - journals.aai.org
Abstract CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate
of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is …
of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is …
Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer
IG Zizzari, A Di Filippo, A Botticelli, L Strigari… - Clinical Cancer …, 2022 - AACR
Purpose: CD137 molecule is expressed by activated lymphocytes, and in patients with
cancer identifies the tumor-reactive T cells. In solid tumors, high levels of circulating CD137+ …
cancer identifies the tumor-reactive T cells. In solid tumors, high levels of circulating CD137+ …
Dendritic cell therapy with CD137L-DC-EBV-VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benefit
E Nickles, B Dharmadhikari, L Yating, RJ Walsh… - Cancer Immunology …, 2022 - Springer
Abstract Introduction Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma
(NPC), and provides a target for a dendritic cell (DC) vaccine. CD137 ligand (CD137L) …
(NPC), and provides a target for a dendritic cell (DC) vaccine. CD137 ligand (CD137L) …
CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses
B Dharmadhikari, M Wu, NS Abdullah… - …, 2016 - Taylor & Francis
ABSTRACT CD137 is expressed on activated T cells and NK cells, among others, and is a
potent co-stimulator of antitumor immune responses. CD137 ligand (CD137L) is expressed …
potent co-stimulator of antitumor immune responses. CD137 ligand (CD137L) is expressed …
Expression of CD137 on Hodgkin and Reed–Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression
WT Ho, WL Pang, SM Chong, A Castella, S Al-Salam… - Cancer research, 2013 - AACR
Hodgkin lymphoma is caused by a minority population of malignant Hodgkin and Reed–
Sternberg (HRS) cells that recruit an abundance of inflammatory cells. The long-term …
Sternberg (HRS) cells that recruit an abundance of inflammatory cells. The long-term …
Boosting antitumor response by costimulatory strategies driven to 4-1BB and OX40 T-cell receptors
DE Mascarelli, RSM Rosa, JM Toscaro… - Frontiers in cell and …, 2021 - frontiersin.org
Immunotherapy explores several strategies to enhance the host immune system's ability to
detect and eliminate cancer cells. The use of antibodies that block immunological …
detect and eliminate cancer cells. The use of antibodies that block immunological …
Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation
HJ Kim, JS Lee, JD Kim, HJ Cha… - Proceedings of the …, 2012 - National Acad Sciences
Renal ischemia-reperfusion injury (IRI) after kidney transplantation is a major cause of
delayed graft function. Even though IRI is recognized as a highly coordinated and specific …
delayed graft function. Even though IRI is recognized as a highly coordinated and specific …