The past 20 years have seen dramatic changes in the delivery of radiation therapy, but the
impact of radiobiology on the clinic has been far less substantial. A major consideration in …

Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …

Radiotherapy is one of the most common treatments for oral cancer. However, in the clinic,
recurrence and metastasis of oral cancer occur after radiotherapy, and the underlying …

Hematologic malignancies (HMs) mainly include acute and chronic leukemia, lymphoma,
myeloma and other heterogeneous tumors that seriously threaten human life and health …

Over the last decade, evidence has emerged to support a role for the antidiabetic drug
metformin in the prevention and treatment of cancer. In particular, recent studies …

Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …

Interest has grown in studying the possible use of well-known anti-diabetic drugs as anti-
cancer agents individually or in combination with, frequently used, chemotherapeutic agents …

There is substantial epidemiological evidence pointing to an increased incidence of breast
cancer and morbidity in obese, prediabetic, and diabetic patients. In vitro studies strongly …

Background Metformin, a primary treatment for diabetes mellitus (DM) patients, is associated
with improved outcomes for diabetic cancer patients fuelling further investigation on its …

Purpose Metformin may have anticancer effects and could improve response to radiotherapy
in several malignancies. We aimed to investigate the effect of metformin on response to …