The immunological and metabolic landscape in primary and metastatic liver cancer

X Li, P Ramadori, D Pfister, M Seehawer… - Nature Reviews …, 2021 - nature.com
The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …

CD44 as a tumor biomarker and therapeutic target

H Xu, M Niu, X Yuan, K Wu, A Liu - Experimental hematology & oncology, 2020 - Springer
CD44, a complex transmembrane glycoprotein, exists in multiple molecular forms, including
the standard isoform CD44s and CD44 variant isoforms. CD44 participates in multiple …

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

A Filliol, Y Saito, A Nair, DH Dapito, LX Yu… - Nature, 2022 - nature.com
Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide,
develops almost exclusively in patients with chronic liver disease and advanced fibrosis …

Characterizing dedifferentiation of thyroid cancer by integrated analysis

H Luo, X Xia, GD Kim, Y Liu, Z Xue, L Zhang, Y Shu… - Science …, 2021 - science.org
Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid
cancer, has been hampered by imprecise and incomplete characterization of its …

Cancer stem cell functions in hepatocellular carcinoma and comprehensive therapeutic strategies

YC Liu, CT Yeh, KH Lin - Cells, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …

Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β‐catenin signaling

X Tian, Y Wu, Y Yang, J Wang, M Niu, S Gao… - Molecular …, 2020 - Wiley Online Library
Tumor‐associated macrophages have important roles in hepatocellular carcinoma (HCC)
initiation and progression. Long noncoding RNAs (lncRNAs) have also been reported to be …

The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription

A Xia, W Yuan, Q Wang, J Xu, Y Gu, L Zhang, C Chen… - Nature cancer, 2022 - nature.com
Cancer-testis (CT) genes participate in the initiation and progression of cancer, but the role
of CT-associated long non-coding RNAs (CT-lncRNAs) in hepatocellular carcinoma (HCC) …

m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance

T Zhou, S Li, D Xiang, J Liu, W Sun, X Cui… - Signal transduction and …, 2020 - nature.com
Hepatocyte nuclear factor 3γ (HNF3γ) is a hepatocyte nuclear factor, but its role and clinical
significance in hepatocellular carcinoma (HCC) remain unclear. Herein, we report that …

Hyaluronic acid as a modern approach in anticancer therapy-review

M Michalczyk, E Humeniuk, G Adamczuk… - International Journal of …, 2022 - mdpi.com
Hyaluronic acid (HA) is a linear polysaccharide and crucial component of the extracellular
matrix (ECM), maintaining tissue hydration and tension. Moreover, HA contributes to …

Molecular bases of drug resistance in hepatocellular carcinoma

JJG Marin, RIR Macias, MJ Monte, MR Romero… - Cancers, 2020 - mdpi.com
The poor outcome of patients with non-surgically removable advanced hepatocellular
carcinoma (HCC), the most frequent type of primary liver cancer, is mainly due to the high …