The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

This review describes the structure of telomeres, the protective DNA-protein complexes at
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …

As the sole site of nucleocytoplasmic transport, the nuclear pore complex (NPC) has a vital
cellular role. Nonetheless, much remains to be learned about many fundamental aspects of …

In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and
translation in the cytoplasm imposes the requirement of transporting thousands of …

DNA damage frequently triggers death by apoptosis. The irreversible decision to die can be
facilitated or forestalled through integration of a wide variety of stimuli from within and …

The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …

Although genetics has an essential role in defining the development, morphology, and
physiology of an organism, epigenetic mechanisms have an essential role in modulating …

Background: In comparison with many nuclear proteins, the movement of chromatin in nuclei
appears to be generally constrained. These restrictions on motion are proposed to reflect the …

The association of genes with the nuclear pore complex (NPC) and nuclear transport factors
has been implicated in transcriptional regulation. We therefore examined the association of …

Through a genetic screen using myosin-like protein strains mlp1 Δ mlp2 Δ and biochemical
purification, we identified a complex of eight proteins, each required for growth and DNA …