Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium

AS Keck, JW Finley - Integrative cancer therapies, 2004 - journals.sagepub.com
Dietetic professionals urge Americans to increase fruit and vegetable intakes. The American
Institute of Cancer Research estimates that if the only dietary change made was to increase …

Proposed criteria for assessing the efficacy of cancer reduction by plant foods enriched in carotenoids, glucosinolates, polyphenols and selenocompounds

JW Finley - Annals of botany, 2005 - academic.oup.com
Background and Aims The cancer-protective properties of vegetable consumption are most
likely mediated through 'bioactive compounds' that induce a variety of physiologic functions …

Potential health benefits of broccoli-a chemico-biological overview

HR Vasanthi, S Mukherjee… - Mini reviews in medicinal …, 2009 - ingentaconnect.com
The concept that bioactive components in functional foods are efficacious for the
improvement of health, has recently gained much importance. The cruciferous vegetables …

The “Prochaska” microtiter plate bioassay for inducers of NQO1

JW Fahey, AT Dinkova-Kostova, KK Stephenson… - Methods in …, 2004 - Elsevier
Publisher Summary This chapter provides details of ''Prochaska''microtiter plate bioassay for
inducers of NQO1. The microtiter plate bioassay for NQO1 was first developed in the …

Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention

E Bertl, H Bartsch, C Gerhauser - Molecular cancer therapeutics, 2006 - AACR
Sulforaphane, an aliphatic isothiocyanate, is a known cancer chemopreventive agent.
Aiming to investigate antiangiogenic potential of sulforaphane, we here report a potent …

Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane …

S Krehl, M Loewinger, S Florian, AP Kipp… - …, 2012 - academic.oup.com
Chronic inflammation and selenium deficiency are considered as risk factors for colon
cancer. The protective effect of selenium might be mediated by specific selenoproteins, such …

Novel insights into redox system and the mechanism of redox regulation

X Wang, C Hai - Molecular Biology Reports, 2016 - Springer
In view of the critical role of redox system in numerous physiological and pathophysiological
processes, it is important to clearly understand the family members and regulatory …

Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential

C Angeloni, E Leoncini, M Malaguti… - Journal of Agricultural …, 2009 - ACS Publications
Oxidative stress plays a major role in the pathophysiology of cardiac disorders, but the
experimental data on the protective effects of exogenous antioxidants are controversial. A …

Alternative to sugar, honey does not provoke insulin resistance in rats based on lipid profiles, inflammation, and IRS/PI3K/AKT signaling pathways modulation

S Chen, F Wu, C Yang, C Zhao, N Cheng… - Journal of Agricultural …, 2022 - ACS Publications
Insulin resistance (IR) is the central link to metabolic syndrome (MS), and IR prevention has
become the key to overcoming this worldwide public health problem. A diet rich in simple …

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers

WD Holtzclaw, AT Dinkova-Kostova… - Advances in enzyme …, 2004 - Elsevier
The projected number of new diagnoses and the prevalence of cancer in the US are
expected to double by the year 2030 (Polednak, 1994, 1997). Improvements in treatment …