The incidence of sepsis is highest in neonates and children, yet the global burden of sepsis
in these age groups has not been assessed. We reviewed available evidence from …

Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance
and perturbations of the developing microbiome. Early-life microbiome disruption increases …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Abstract Purpose The Sepsis-3 consensus task force defined sepsis as life-threatening
organ dysfunction caused by dysregulated host response to infection. However, the clinical …

Objective To assess the epidemiology of blood culture-proven early-(EOS) and late-onset
neonatal sepsis (LOS). Study design All newborn infants admitted to tertiary care neonatal …

Objective: To determine the associations of demographic, clinical, laboratory, organ
dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic …

CONCLUSIONS The recent introduction of Sepsis-3 for adults has triggered plans to
translate this to children and newborn infants and involvement in the Surviving Sepsis …

Background Sepsis is one of the main reasons for non-elective admission to pediatric
intensive care units (PICUs), but little is known about determinants influencing outcome. We …

Antimicrobial susceptibility testing (AST) of bacteria isolated in blood cultures is critical for
optimal management of patients with sepsis. This review describes new and emerging …

Objectives: Sepsis is responsible for a substantial proportion of global childhood morbidity
and mortality. However, evidence demonstrates major inaccuracies in the use of the term …