Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen
storage, oxygen activation, and electron transfer when bound to the heme proteins …

Asymmetric hydrogenation of activated olefins using transition metal catalysis is a powerful
tool for the synthesis of complex molecules, but traditional metal catalysts have difficulty with …

Acanthamoeba castellanii is a free-living amoeba that can cause severe eye and brain
infections in humans. At present, there is no uniformly effective treatment for any of these …

Organisms have evolved signal transduction systems to quickly adapt their lifestyle to
internal and environmental changes. While protein kinases and two‐component systems are …

Reactive sulfur species (RSS) are involved in bioactive regulation via persulfidation of
proteins. However, how cells regulate RSS-based signaling and RSS metabolism is poorly …

The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP
isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as …

His/Cys coordination was recently found in several c-type cytochromes, which could act as
sensors, in electron transport or in regulation. Toward a better understanding of Cys function …

In this thesis, combined vibrational spectroscopy and electrochemistry is applied to
investigate two different projects in biological and materials sciences. In the biological …

The ability to rapidly respond to changes in the environment or inside the cell is essential for
survival of organisms. A variety of mechanisms evolved to monitor critical parameters like eg …

The sensor kinases MsmS and RdmS from the methanogenic archaeon Methanosarcina
acetivorans are multidomain proteins containing a covalently linked heme cofactor. This …