Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres
T Shimizu, A Lengalova, V Martínek… - Chemical Society …, 2019 - pubs.rsc.org
Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen
storage, oxygen activation, and electron transfer when bound to the heme proteins …
storage, oxygen activation, and electron transfer when bound to the heme proteins …
Fe/Thiol Cooperative Hydrogen Atom Transfer Olefin Hydrogenation: Mechanistic Insights That Inform Enantioselective Catalysis
SR Buzsaki, SM Mason, PV Kattamuri… - Journal of the …, 2024 - ACS Publications
Asymmetric hydrogenation of activated olefins using transition metal catalysis is a powerful
tool for the synthesis of complex molecules, but traditional metal catalysts have difficulty with …
tool for the synthesis of complex molecules, but traditional metal catalysts have difficulty with …
Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51
K Nienhaus, V Sharma, GU Nienhaus, LM Podust - Biochemistry, 2022 - ACS Publications
Acanthamoeba castellanii is a free-living amoeba that can cause severe eye and brain
infections in humans. At present, there is no uniformly effective treatment for any of these …
infections in humans. At present, there is no uniformly effective treatment for any of these …
Thiol‐based redox sensing in the methyltransferase associated sensor kinase RdmS in Methanosarcina acetivorans
K Fiege, N Frankenberg‐Dinkel - Environmental microbiology, 2019 - Wiley Online Library
Organisms have evolved signal transduction systems to quickly adapt their lifestyle to
internal and environmental changes. While protein kinases and two‐component systems are …
internal and environmental changes. While protein kinases and two‐component systems are …
Repressor activity of SqrR, a master regulator of persulfide-responsive genes, is regulated by heme coordination
T Shimizu, Y Hayashi, M Arai… - Plant and Cell …, 2021 - academic.oup.com
Reactive sulfur species (RSS) are involved in bioactive regulation via persulfidation of
proteins. However, how cells regulate RSS-based signaling and RSS metabolism is poorly …
proteins. However, how cells regulate RSS-based signaling and RSS metabolism is poorly …
Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
K Frydenvang, MCA Verkade-Vreeker, F Dohmen… - Plos one, 2019 - journals.plos.org
The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP
isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as …
isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as …
Protonation of the Cysteine Axial Ligand Investigated in His/Cys c-Type Cytochrome by UV–Vis and Mid- and Far-IR Spectroscopy
L Zuccarello, C Berthomieu, A Boussac… - The Journal of …, 2020 - ACS Publications
His/Cys coordination was recently found in several c-type cytochromes, which could act as
sensors, in electron transport or in regulation. Toward a better understanding of Cys function …
sensors, in electron transport or in regulation. Toward a better understanding of Cys function …
[PDF][PDF] Combined vibrational spectroscopy and electrochemistry for studying biological and materials systems
CJU Querebillo - 2020 - depositonce.tu-berlin.de
In this thesis, combined vibrational spectroscopy and electrochemistry is applied to
investigate two different projects in biological and materials sciences. In the biological …
investigate two different projects in biological and materials sciences. In the biological …
[PDF][PDF] Eidesstattliche Erklärung
K Fiege - kluedo.ub.rptu.de
The ability to rapidly respond to changes in the environment or inside the cell is essential for
survival of organisms. A variety of mechanisms evolved to monitor critical parameters like eg …
survival of organisms. A variety of mechanisms evolved to monitor critical parameters like eg …
Spectroscopic characterization of the heme binding (GAF) domain of two sensor kinases from Methanosarcina acetivorans
K Fiege, C Twittenhoff, K Kwiatkowski… - Journal of Porphyrins …, 2019 - World Scientific
The sensor kinases MsmS and RdmS from the methanogenic archaeon Methanosarcina
acetivorans are multidomain proteins containing a covalently linked heme cofactor. This …
acetivorans are multidomain proteins containing a covalently linked heme cofactor. This …