Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …

There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Cellular reprogramming can manipulate the identity of cells to generate the desired cell
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …

The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …

After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex
systems. However, a comprehensive single-cell atlas has not been achieved for humans …

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …

Current understandings of cell specification in early mammalian pre-implantation
development are based mainly on mouse studies. The first lineage differentiation event …