Novel thiadiazol derivatives; design, synthesis, biological activity, molecular docking and molecular dynamics
Currently, selective COX-2 inhibitors are used as a novel alternative approach in the course
of pain management due to their reduced adverse that generally occur after COX-1 …
of pain management due to their reduced adverse that generally occur after COX-1 …
Synthesis, crystal structure, DFT and Hirshfeld surface analysis of 4-fluoro-N-(1, 3-dioxoisoindolin-2-yl) benzamide
R Elancheran, B Karthikeyan, S Srinivasan… - European Journal of …, 2023 - eurjchem.com
Abstract The 4-fluoro-N-(1, 3-dioxoisoindolin-2-yl) benzamide was synthesized by the
reaction of 4-fluorobenzohydrazide with phthalic anhydride in acetic acid. The compound …
reaction of 4-fluorobenzohydrazide with phthalic anhydride in acetic acid. The compound …
[HTML][HTML] Integrated metabolomics and network pharmacology to decipher the latent mechanisms of protopanaxatriol against acetic acid-induced gastric ulcer
C Wang, L Tan, J Liu, D Fu, C Wang, P Li, Z Li… - International Journal of …, 2022 - mdpi.com
Gastric ulcer (GU) is a peptic disease with high morbidity and mortality rates affecting
approximately 4% of the population throughout the world. Current therapies for GU are …
approximately 4% of the population throughout the world. Current therapies for GU are …
Novel quinazolinone Derivatives: Design, synthesis and in vivo evaluation as potential agents targeting Alzheimer disease
HK Moftah, MHA Mousa, EZ Elrazaz, AS Kamel… - Bioorganic …, 2024 - Elsevier
Since Alzheimer disease is one of the most prevalent types of dementia with a high mortality
and disability rate, so development of multi-target drugs becomes the major strategy for …
and disability rate, so development of multi-target drugs becomes the major strategy for …
New 2-aminobenzothiazole derivatives: Design, synthesis, anti-inflammatory and ulcerogenicity evaluation
SS Awaad, MO Sarhan, WR Mahmoud, T Nasr… - Journal of Molecular …, 2023 - Elsevier
Two series of twenty diversely substituted benzothiazole amides were designed and
synthesized aiming to obtain derivatives with potential anti-inflammatory activity and …
synthesized aiming to obtain derivatives with potential anti-inflammatory activity and …
Discovery of new 2-(3-(naphthalen-2-yl)-4, 5-dihydro-1H-pyrazol-1-yl) thiazole derivatives with potential analgesic and anti-inflammatory activities: In vitro, in vivo and …
ER Mohammed, AH Abd-El-Fatah, AR Mohamed… - Bioorganic …, 2024 - Elsevier
Joining the global demand for the discovery of potent NSAIDs with minimized ulcerogenic
effect, new pyrazole clubbed thiazole derivatives 5a-o were designed and synthesized. The …
effect, new pyrazole clubbed thiazole derivatives 5a-o were designed and synthesized. The …
Design, synthesis and anti-inflammatory assessment of certain substituted 1, 2, 4-triazoles bearing tetrahydroisoquinoline scaffold as COX 1/2-inhibitors
MI Abo-Elmagd, RM Hassan, ME Aboutabl, KM Amin… - Bioorganic …, 2024 - Elsevier
Aiming to discover effective and safe non-steroidal anti-inflammatory agents, a new set of 1,
2, 4-triazole tetrahydroisoquinoline hybrids 9a-g, 11a-g and 12a-g was synthesized and …
2, 4-triazole tetrahydroisoquinoline hybrids 9a-g, 11a-g and 12a-g was synthesized and …
Design and Synthesis of Novel Fluorescent 2-(aryloxy)-3-(4,5-diaryl)-1H-imidazol-2-yl)quinolines: Solvatochromic, DFT, TD-DFT Studies, COX-1 and COX-2 Inhibition …
The present work focuses on the synthesis of novel heterocycles 2-(aryloxy)-3-(4, 5-diaryl-1
H-imidazol-2-yl) quinolines (6k-v) by an effective condensation reaction. These molecules …
H-imidazol-2-yl) quinolines (6k-v) by an effective condensation reaction. These molecules …