The benefits of antipsychotic medications are sometimes obscured by their adverse effects.
These effects range from relatively minor tolerability issues (eg, mild sedation or dry mouth) …

Since the discovery of chlorpromazine (CPZ) in 1952, first-generation antipsychotics (FGAs)
have revolutionized psychiatric care in terms of facilitating discharge from hospital and …

The content of these European Society of Cardiology (ESC) Guidelines has been published
for personal and educational use only. No commercial use is authorized. No part of the ESC …

Orthostatic hypotension (OH) is an abnormal blood pressure response to standing, which is
associated with an increased risk of adverse outcomes such as syncope, falls, cognitive …

Background Antipsychotics are a cornerstone of pharmacological treatment of
schizophrenia. Improved understanding of the dose-response relationship of antipsychotics …

Patients with mental disorders have an increased risk to develop cardiovascular disease
(CVD), and CVD are frequently comorbid with especially adjustment, anxiety and depressive …

Aripiprazole, brexpiprazole and cariprazine differ from all other second-generation
antipsychotics due to partial agonism at the dopamine D2 and D3 receptors. In contrast to …

Introduction There are several new and emerging antipsychotic medication strategies
recently marketed or under clinical development for the treatment of several mental …

Introduction: Patients living with schizophrenia have a marked risk of clinically significant
weight gain and obesity compared to the general population. The risks have been …

The use of antipsychotics is hindered by the frequent occurrence of metabolic and
cardiovascular side effects, resulting in worsened quality of life and greater mortality as a …