For over 35 years since Mosmann and Coffman proposed the seminal “type 1 T helper
(Th1)/type 2 T helper (Th2)” hypothesis in 1986, the immunological community has …

Interleukin (IL)-6-type cytokines are critically involved in health and disease. The duration
and strength of IL-6-type cytokine-mediated signaling is tightly regulated to avoid …

Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-
sized artery walls. The molecular mechanisms regulating the onset and progression of …

IL-12 is a potent inducer of IFN-γ production and promotes a protective cell-mediated
immune response after Mycobacterium tuberculosis infection. Recently, the IL-12-related …

The recent identification of IL-27 (IL-27p28/EBV-induced gene 3) and IL-27R (WSX-
1/gp130) has provided new insights for the biology of IL-6/IL-12 family cytokines. Initial …

The intestinal immune system has the challenge of maintaining both a state of tolerance
toward intestinal antigens and the ability to combat pathogens. This balance is partially …

AIM OF THE STUDY: A herbal preparation using Scutellaria baicalensis (S. baicalensis)
Georgi (Huang Qin, SB) was formulated to effectively protect cancer patients from …

Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic,
destructive, debilitating arthritis. Its etiology is unknown; it is presumed that environmental …

The lethal outcome of high-dose pulmonary virus infection is thought to reflect high-level,
sustained virus replication and associated lung inflammation prior to development of an …

Minocycline has immunomodulatory and neuroprotective activities in vitro and in an animal
model of multiple sclerosis (MS). We have previously reported that minocycline decreased …