Neurofilament light chain in blood as a diagnostic and predictive biomarker for multiple sclerosis: A systematic review and meta-analysis

L Ning, B Wang - PLoS One, 2022 - journals.plos.org
Background Neurofilament light chain (NfL) in cerebrospinal fluid (CSF) is a biomarker of
multiple sclerosis (MS). However, CSF sampling is invasive and has limited the clinical …

[HTML][HTML] Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis management

MS Freedman, S Gnanapavan, RA Booth… - …, 2024 - thelancet.com
Neurofilament light chain (NfL) is a long-awaited blood biomarker that can provide clinically
useful information about prognosis and therapeutic efficacy in multiple sclerosis (MS). There …

Contributors to serum NfL levels in people without neurologic disease

KC Fitzgerald, ES Sotirchos, MD Smith… - Annals of …, 2022 - Wiley Online Library
Objective To assess the effects of demographics, lifestyle factors, and comorbidities on
serum neurofilament light chain (sNfL) levels in people without neurologic disease and …

Glial fibrillary acidic protein as a biomarker in neuromyelitis optica spectrum disorder: a current review

P Schindler, O Aktas, M Ringelstein… - Expert Review of …, 2023 - Taylor & Francis
Introduction Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, often
debilitating neuroinflammatory disease, whose predominant clinical manifestations are …

Validity of serum neurofilament light chain as a prognostic biomarker of disease activity in multiple sclerosis

MK Sen, MJ Hossain, DA Mahns, BJ Brew - Journal of Neurology, 2023 - Springer
Multiple sclerosis (MS) is a chronic demyelinating and neuroinflammatory disease of the
human central nervous system with complex pathoetiology, heterogeneous presentations …

Serum neurofilament light chain levels at attack predict post-attack disability worsening and are mitigated by inebilizumab: analysis of four potential biomarkers in …

O Aktas, HP Hartung, MA Smith, WA Rees… - Journal of Neurology …, 2023 - jnnp.bmj.com
Objective To investigate relationships between serum neurofilament light chain (sNfL),
ubiquitin C-terminal hydrolase L1 (sUCHL1), tau (sTau) and glial fibrillary acidic protein …

Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis

S Brune, EA Høgestøl… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: Serum neurofilament light (sNfL) chain is a promising biomarker reflecting
neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict …

Fluid biomarkers in multiple sclerosis: from current to future applications

M Di Filippo, L Gaetani, D Centonze… - The Lancet Regional …, 2024 - thelancet.com
Multiple sclerosis (MS) is an immune-mediated inflammatory and degenerative disorder of
the central nervous system (CNS) with heterogeneous clinical manifestations. In the last …

Recommendations for the diagnosis and treatment of multiple sclerosis relapses

C Ramo-Tello, Y Blanco, L Brieva, B Casanova… - Journal of Personalized …, 2021 - mdpi.com
Minimizing the risk of relapse is essential in multiple sclerosis (MS). As none of the
treatments currently available are capable of completely preventing relapses, treatment of …

Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis

C Noll, M Hiltensperger, L Aly, R Wicklein… - Frontiers in …, 2022 - frontiersin.org
Background Optical coherence tomography angiography (OCT-A) is a novel technique
allowing non-invasive assessment of the retinal vasculature. During relapsing remitting …