Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals.
The disease was initially described in the 16th century and was the first animal pathogen …

▪ Abstract Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …

The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

The ribosome scanning model predicts that eukaryotic ribosomal 40 S subunits enter all
messenger RNAs at their 5′ ends. Here, it is reported that eukaryotic ribosomes can initiate …

Translation initiation is a complex process in which initiator tRNA, 40S, and 60S ribosomal
subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the …

To elucidate an outline of the mechanism of eukaryotic translation initiation, 48S complex
formation was analyzed on defined mRNAs in reactions reconstituted in vitro from fully …

In positive-stranded viruses, the genomic RNA serves as a template for both translation and
RNA replication. Using poliovirus as a model, we examined the interaction between these …

Pre‐mRNA is processed as a large complex of pre‐mRNA, snRNPs and pre‐mRNA binding
proteins (hnRNP proteins). The significance of hnRNP proteins in mRNA biogenesis is likely …

In higher eukaryotes, the polypyrimidine-tract (Py-tract) adjacent to the 3′ splice site is
recognized by several proteins, including the essential splicing factor U2AF65, the splicing …

The scanning model of translation initiation is a coherent description of how eukaryotic
ribosomes reach the initiation codon after being recruited to the capped 5′ end of …