The majority of exchanges of oxygen and nutrients are performed around vessels smaller
than 100 μm, allowing cells to thrive everywhere in the body. Pathologies such as cancer …

Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …

Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-
brain barrier (BBB) to increase therapeutic agent penetration at the targeted brain site to …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which is mainly
characterized by progressive impairment in cognition, emotion, language and memory in …

Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

Applications of ultrasound in medicine for therapeutic purposes have been accepted and
beneficial uses of ultrasonic biological effects for many years. Low‐power ultrasound of …

Cavitation-facilitated microbubble-mediated focused ultrasound therapy is a promising
method of drug delivery across the blood–brain barrier (BBB) for treating many neurological …

Nucleic acids are a promising type of therapeutic for the treatment of a wide range of
conditions, including cancer, but they also pose many delivery challenges. For efficient and …

The blood–brain barrier (BBB) prevents entry of most drugs into the brain and is a major
hurdle to the use of drugs for brain tumors and other central nervous system disorders. Work …

The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …