The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …

BACKGROUND The first small follicles to appear in the mammalian ovaries are primordial
follicles. The initial pool of primordial follicles serves as the source of developing follicles …

Data derived principally from peripheral tissues (fat, muscle and liver) show that insulin
signals via diverse interconnecting intracellular pathways and that some of the major …

This review aimed to focus on the recent progress of the understanding of the role of
phosphatidylinositol 3-kinase (PI3K) in polycystic ovary syndrome (PCOS). In recent years, it …

Purpose Mammalian oogenesis and folliculogenesis share a dynamic connection that is
critical for gamete development. For maintenance of quiescence or follicular activation …

Cancer therapy can cause off-target effects including ovarian damage, which may result in
primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles …

STUDY QUESTION Is ceramide-1-phosphate (C1P) an ovarian protective agent during
alkylating chemotherapy? SUMMARY ANSWER Local administration of C1P drastically …

This review focuses on the role of the dialog between the oocyte and its companion somatic
cells in driving folliculogenesis from the primordial to the preovulatory follicle stage. Mouse …

Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target
effect. However, their oocyte death pathway has been debated. Here, we clarified the …

Development of early follicles, especially the activation of primordial follicles, is strictly
modulated by a network of signaling pathways. Recent advance in ovarian physiology has …