Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy
Single-particle analysis by electron microscopy is a well established technique for analyzing
the three-dimensional structures of biological macromolecules. Besides its ability to produce …
the three-dimensional structures of biological macromolecules. Besides its ability to produce …
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation
The CorA family of proteins regulates the homeostasis of divalent metal ions in many
bacteria, archaea, and eukaryotic mitochondria, making it an important target in the …
bacteria, archaea, and eukaryotic mitochondria, making it an important target in the …
Mechanism of transmembrane signaling by sensor histidine kinases
INTRODUCTION Microorganisms obtain most of the information about their environments
through membrane-associated signaling systems. One of the most abundant classes of …
through membrane-associated signaling systems. One of the most abundant classes of …
Structural insights into the catalytic cycle of a bacterial multidrug ABC efflux pump
W Javed, S Vallet, MP Clement, A Le Roy… - Journal of molecular …, 2022 - Elsevier
Abstract ABC (“ATP-Binding Cassette”) transporters of the type IV subfamily consist of
exporters involved in the efflux of many compounds, notably those capable to confer …
exporters involved in the efflux of many compounds, notably those capable to confer …
[HTML][HTML] Comprehensive collection and prediction of ABC transmembrane protein structures in the AI era of structural biology
The number of unique transmembrane (TM) protein structures doubled in the last four years,
which can be attributed to the revolution of cryo-electron microscopy. In addition, AlphaFold2 …
which can be attributed to the revolution of cryo-electron microscopy. In addition, AlphaFold2 …
Smooth orientation-dependent scoring function for coarse-grained protein quality assessment
Motivation Protein quality assessment (QA) is a crucial element of protein structure
prediction, a fundamental and yet open problem in structural bioinformatics. QA aims at …
prediction, a fundamental and yet open problem in structural bioinformatics. QA aims at …
VoroCNN: deep convolutional neural network built on 3D Voronoi tessellation of protein structures
Motivation Effective use of evolutionary information has recently led to tremendous progress
in computational prediction of three-dimensional (3D) structures of proteins and their …
in computational prediction of three-dimensional (3D) structures of proteins and their …
A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6: 6 assemblies
M Gurusaran, OR Davies - elife, 2021 - elifesciences.org
The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex mechanically couples
cytoskeletal and nuclear components across the nuclear envelope to fulfil a myriad of …
cytoskeletal and nuclear components across the nuclear envelope to fulfil a myriad of …
[HTML][HTML] Novel xylose transporter Cs4130 expands the sugar uptake repertoire in recombinant Saccharomyces cerevisiae strains at high xylose concentrations
JGR Bueno, G Borelli, TLR Corrêa… - Biotechnology for …, 2020 - Springer
Background The need to restructure the world's energy matrix based on fossil fuels and
mitigate greenhouse gas emissions stimulated the development of new biobased …
mitigate greenhouse gas emissions stimulated the development of new biobased …
[HTML][HTML] Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD
The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a
reversible inactivating post-translational modification. Both BiP AMPylation and …
reversible inactivating post-translational modification. Both BiP AMPylation and …