The market of chiral drugs: Chiral switches versus de novo enantiomerically pure compounds

A Calcaterra, I D'Acquarica - Journal of pharmaceutical and biomedical …, 2018 - Elsevier
This review article is aimed at providing an overview of the current market of chiral drugs by
exploring which is the nowadays tendency, for the pharmaceutical industry, either to exploit …

The many faces of packed column supercritical fluid chromatography–A critical review

E Lesellier, C West - Journal of Chromatography A, 2015 - Elsevier
Packed column sub-and supercritical fluid chromatography (SFC) is a versatile separation
method: on the one hand the number of parameters acting on the quality of a separation is …

Chiral recognition by enantioselective liquid chromatography: mechanisms and modern chiral stationary phases

M Lämmerhofer - Journal of Chromatography A, 2010 - Elsevier
An overview of the state-of-the-art in LC enantiomer separation is presented. This tutorial
review is mainly focused on mechanisms of chiral recognition and enantiomer distinction of …

Determination of absolute configuration of chiral molecules using vibrational optical activity: a review

Y He, W Bo, RK Dukor, LA Nafie - Applied Spectroscopy, 2011 - opg.optica.org
Determination of the absolute handedness, known as absolute configuration (AC), of chiral
molecules is an important step in any field related to chirality, especially in the …

[图书][B] Chiroptical spectroscopy: fundamentals and applications

PL Polavarapu - 2016 - taylorfrancis.com
This book details chiroptical spectroscopic methods: electronic circular dichroism (ECD),
optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational …

Luminescent chiral lanthanide (III) complexes as potential molecular probes

G Muller - Dalton Transactions, 2009 - pubs.rsc.org
This perspective gives an introduction into the design of luminescent lanthanide (III)-
containing complexes possessing chiral properties and used to probe biological materials …

Detecting chirality in molecules by imaging photoelectron circular dichroism

MHM Janssen, I Powis - Physical Chemistry Chemical Physics, 2014 - pubs.rsc.org
In this Perspective we discuss photoelectron circular dichroism (PECD), a relatively novel
technique that can detect chiral molecules with high sensitivity. PECD has an enantiomeric …

Assignment of the absolute configuration of polyfunctional compounds by NMR using chiral derivatizing agents

JM Seco, E Quiñoá, R Riguera - Chemical reviews, 2012 - ACS Publications
1. INTRODUCTION AND SCOPE Interest in determining the absolute stereochemistry of a
chiral organic compound stems from the widely recognized fact that the stereochemistry …

Time-dependent density functional response theory for electronic chiroptical properties of chiral molecules

J Autschbach, L Nitsch-Velasquez… - Electronic and magnetic …, 2011 - Springer
Methodology to calculate electronic chiroptical properties from time-dependent density
functional theory (TDDFT) is outlined. Applications of TDDFT to computations of electronic …

Innovative chiral resolution using enantiospecific co-crystallization in solution

G Springuel, T Leyssens - Crystal growth & design, 2012 - ACS Publications
A large number of active pharmaceutical ingredients (API) are chiral. Most of them are
synthesized as racemic mixtures, and a chiral resolution step is introduced somewhere …