Process engineering of human pluripotent stem cells for clinical application
Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem
cells, constitute an extremely attractive tool for cell therapy. However, flexible platforms for …
cells, constitute an extremely attractive tool for cell therapy. However, flexible platforms for …
Concise review: the evolution of human pluripotent stem cell culture: from feeder cells to synthetic coatings
Current practices to maintain human pluripotent stem cells (hPSCs), which include induced
pluripotent stem cells and embryonic stem cells, in an undifferentiated state typically depend …
pluripotent stem cells and embryonic stem cells, in an undifferentiated state typically depend …
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
K Amps, PW Andrews, G Anyfantis… - Nature …, 2011 - search.ebscohost.com
Abstract The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell
lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for …
lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for …
Role of E-cadherin and other cell adhesion molecules in survival and differentiation of human pluripotent stem cells
L Li, SAL Bennett, L Wang - Cell adhesion & migration, 2012 - Taylor & Francis
The survival, proliferation, self-renewal and differentiation of human pluripotent stem cells
(hPSCs, including human embryonic stem cells and human induced pluripotent stem cells) …
(hPSCs, including human embryonic stem cells and human induced pluripotent stem cells) …
Highly efficient genome editing via CRISPR–Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression
Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for
functional genomics, disease modeling, and regenerative medicine. However, low editing …
functional genomics, disease modeling, and regenerative medicine. However, low editing …
Genomic instability in pluripotent stem cells: implications for clinical applications
SE Peterson, JF Loring - Journal of Biological Chemistry, 2014 - ASBMB
Human pluripotent stem cells (hPSCs) are known to acquire genomic changes as they
proliferate and differentiate. Despite concerns that these changes will compromise the safety …
proliferate and differentiate. Despite concerns that these changes will compromise the safety …
Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis
Human embryonic stem (hES) cells activate a rapid apoptotic response after DNA damage
but the underlying mechanisms are unknown. A critical mediator of apoptosis is Bax, which …
but the underlying mechanisms are unknown. A critical mediator of apoptosis is Bax, which …
iPS-cell technology and the problem of genetic instability—Can it ever be safe for clinical use?
SW Attwood, MJ Edel - Journal of clinical medicine, 2019 - mdpi.com
The use of induced Pluripotent Stem Cells (iPSC) as a source of autologous tissues shows
great promise in regenerative medicine. Nevertheless, several major challenges remain to …
great promise in regenerative medicine. Nevertheless, several major challenges remain to …
Gain of 20q11. 21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL
HT Nguyen, M Geens, A Mertzanidou… - Molecular human …, 2014 - academic.oup.com
Abstract Gain of 20q11. 21 is a chromosomal abnormality that is recurrently found in human
pluripotent stem cells and cancers, strongly suggesting that this mutation confers a …
pluripotent stem cells and cancers, strongly suggesting that this mutation confers a …
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage
Nature biotechnology, 2011 - nature.com
Abstract The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell
lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for …
lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for …