The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Objective: Lipodystrophy syndromes are extremely rare disorders of deficient body fat
associated with potentially serious metabolic complications, including diabetes …

Type 2 diabetes mellitus and hypertension overlap in the population. In many subjects,
development of diabetes mellitus is characterized by a relatively rapid increase in plasma …

Diabetes mellitus are complex, multi‐organ metabolic pathologies characterized by
hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT …

Leptin has emerged over the past 2 decades as a key hormone secreted by adipose tissue
that conveys information on energy stores. Leptin is considered an important regulator of …

Metabolic syndrome defines a cluster of interrelated risk factors for cardiovascular disease
and diabetes mellitus. These factors include metabolic abnormalities, such as …

Although visceral obesity is recognized as a risk factor for cardiovascular diseases (CVDs),
the efficacy of omental fat removal in CVD treatment is still controversial. There is a need to …

Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular
morbidity and mortality that is seen in both hypertensive and normotensive populations …

Obesity and hypertension are intimately linked due to the various ways that the important
cell types such as vascular smooth muscle cells (VSMC), endothelial cells (EC), immune …

Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of
energy balance and metabolism through humoral and neural pathways. Leptin acts on the …