Stimuli-responsive therapeutic metallodrugs
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …
metal-based drugs for several decades, whereas problems such as drug-resistance and …
The medicinal chemistry of ferrocene and its derivatives
Ferrocene derivatives have attracted significant interest as anticancer, antibacterial,
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …
Recent developments in 1, 6-addition reactions of para-quinone methides (p-QMs)
JY Wang, WJ Hao, SJ Tu, B Jiang - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
In recent years, para-quinone methides (p-QMs) have emerged as attractive and versatile
synthons in organic synthesis owing to their high reactivity. Consequently, p-QM chemistry …
synthons in organic synthesis owing to their high reactivity. Consequently, p-QM chemistry …
Ferrocifen type anti cancer drugs
Despite current developments in therapeutics focusing on biotechnologically-oriented
species, the unflagging utility of small molecules or peptides in medicine is still producing …
species, the unflagging utility of small molecules or peptides in medicine is still producing …
Metal complexes for therapeutic applications
Metal complexes have been widely used for applications in the chemical and physical
sciences due to their unique electronic and stereochemical properties. For decades the use …
sciences due to their unique electronic and stereochemical properties. For decades the use …
[HTML][HTML] Exploration of the medical periodic table: towards new targets
NPE Barry, PJ Sadler - Chemical Communications, 2013 - pubs.rsc.org
Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …
the metal, its oxidation state, the types and number of coordinated ligands and the …
The potential of organometallic complexes in medicinal chemistry
G Gasser, N Metzler-Nolte - Current opinion in chemical biology, 2012 - Elsevier
Organometallic complexes have unique physico-chemical properties, which have been
widely used in homogenous catalysis, for example, for the synthesis of lead compounds and …
widely used in homogenous catalysis, for example, for the synthesis of lead compounds and …
para‐Quinone Methides as Acceptors in 1,6‐Nucleophilic Conjugate Addition Reactions for the Synthesis of Structurally Diverse Molecules
para‐Quinone methides (p‐QMs) are naturally occurring molecules that have been finding
increasing synthetic applications in the last few years. The presence of two electronically …
increasing synthetic applications in the last few years. The presence of two electronically …
Copper‐Catalyzed Enantioselective 1,6‐Boration of para‐Quinone Methides and Efficient Transformation of gem‐Diarylmethine Boronates to Triarylmethanes
Y Lou, P Cao, T Jia, Y Zhang, M Wang… - Angewandte …, 2015 - Wiley Online Library
Presented is the first enantioselective copper‐catalyzed 1, 6‐conjugate addition of bis
(pinacolato) diboron to para‐quinone methides. The reaction proceeds with excellent yields …
(pinacolato) diboron to para‐quinone methides. The reaction proceeds with excellent yields …
Underestimated potential of organometallic rhenium complexes as anticancer agents
A Leonidova, G Gasser - ACS chemical biology, 2014 - ACS Publications
In the recent years, organometallic compounds have become recognized as promising anti-
cancer drug candidates. While radioactive 186/188Re compounds are already used in …
cancer drug candidates. While radioactive 186/188Re compounds are already used in …