Macroautophagy is an evolutionarily conserved process that delivers diverse cellular
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …

Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein
aggregates. Autophagy is particularly important in neurons, which are terminally …

The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …

Parkinson's disease (PD) is the second most common neurodegenerative disorder and the
fastest growing neurologic disease in the world, yet no disease-modifying therapy is …

Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …

Alzheimer's disease (AD) starts from pure cognitive impairments and gradually progresses
into degeneration of specific brain circuits. Although numerous factors initiating AD have …

Neurons are known to rely on autophagy for removal of defective proteins or organelles to
maintain synaptic neurotransmission and counteract neurodegeneration. In spite of its …

Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …