Simple Summary Several factors, both patient-and disease-related, are essential to
accurately estimate acute myeloid leukemia (AML) prognosis. The rapidly evolving field …

The cohesin complex controls faithful chromosome segregation by pairing sister chromatids
after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional …

Core-binding factor (CBF) acute myeloid leukemia (AML) encompasses AML with inv
(16)(p13. 1q22) and AML with t (8; 21)(q22; q22. 1). Despite sharing a common pathogenic …

Studies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML)
based on Western populations. It is unknown to what extent the current genomic findings …

Several canonical translocations produce oncofusion genes that can initiate acute myeloid
leukemia (AML). Although each translocation is associated with unique features, the …

In recent years there have been major advances in the use of molecular diagnostic and
monitoring techniques for patients with acute myeloid leukaemia (AML). Coupled with the …

Cohesin is a multisubunit protein complex that forms a ring-like structure around DNA. It is
essential for sister chromatid cohesion, chromatin organization, transcriptional regulation …

Drug resistance impedes the long-term effect of targeted therapies in acute myeloid
leukemia (AML), necessitating the identification of mechanisms underlying resistance …

In myeloid malignancies including acute myeloid leukemia (AML) and myelodysplastic
syndromes (MDS), patient selection and therapeutic strategies are increasingly based on …

HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is
composed of six members classified by size into large (HERC1 and HERC2) and small …