Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …

Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …

Abstract Background: Kallikreins (KLKs) are a group of 15 secreted serine proteases. Some
KLKs are established or candidate cancer biomarkers, but for most the physiological …

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …

Kallikrein-related peptidases constitute a single family of 15 (chymo) trypsin-like proteases
(KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been …

Insulin-like growth factors were discovered more than 50 years ago as mediators of growth
hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the …

Including the true tissue kallikrein KLK1, kallikrein-related peptidases (KLKs) represent a
family of fifteen mammalian serine proteases. While the physiological roles of several KLKs …

Human tissue kallikreins (KLKs or kallikrein-related peptidases) are a subgroup of
extracellular serine proteases that act on a wide variety of physiological substrates, while …

The human kallikrein (KLK)-related peptidases are the largest family of serine peptidases,
comprising 15 members (KLK1–15) and with the majority (KLK4–15) being identified only …

Cancer is the second leading cause of death with 14 million new cases and 8.2 million
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …