A new perspective on NAFLD: Focusing on lipid droplets

E Scorletti, RM Carr - Journal of hepatology, 2022 - Elsevier
Lipid droplets (LDs) are complex and metabolically active organelles. They are composed of
a neutral lipid core surrounded by a monolayer of phospholipids and proteins. LD …

Dynamics and functions of lipid droplets

JA Olzmann, P Carvalho - Nature reviews Molecular cell biology, 2019 - nature.com
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis

C Sztalryd, DL Brasaemle - Biochimica et biophysica acta (bba)-molecular …, 2017 - Elsevier
Lipid droplets in chordates are decorated by two or more members of the perilipin family of
lipid droplet surface proteins. The perilipins sequester lipids by protecting lipid droplets from …

Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Mechanism and determinants of amphipathic helix-containing protein targeting to lipid droplets

C Prévost, ME Sharp, N Kory, Q Lin, GA Voth… - Developmental cell, 2018 - cell.com
Cytosolic lipid droplets (LDs) are the main storage organelles for metabolic energy in most
cells. They are unusual organelles that are bounded by a phospholipid monolayer and …

Pragmatic coarse-graining of proteins: models and applications

L Borges-Araújo, I Patmanidis, AP Singh… - Journal of Chemical …, 2023 - ACS Publications
The molecular details involved in the folding, dynamics, organization, and interaction of
proteins with other molecules are often difficult to assess by experimental techniques …

The many faces of amphipathic helices

M Giménez-Andrés, A Čopič, B Antonny - Biomolecules, 2018 - mdpi.com
Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their
structure and by the segregation of hydrophobic and polar residues between two faces of …

Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome

S Rogers, L Gui, A Kovalenko, V Zoni… - Journal of Cell …, 2022 - rupress.org
Lipid droplets (LDs) are reservoirs for triglycerides (TGs) and sterol-esters (SEs), but how
these lipids are organized within LDs and influence their proteome remain unclear. Using in …

Perilipins at a glance

CP Najt, M Devarajan, DG Mashek - Journal of cell science, 2022 - journals.biologists.com
Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy
metabolism, membrane synthesis and production of lipid-derived signaling molecules. While …