A new perspective on NAFLD: Focusing on lipid droplets
E Scorletti, RM Carr - Journal of hepatology, 2022 - Elsevier
Lipid droplets (LDs) are complex and metabolically active organelles. They are composed of
a neutral lipid core surrounded by a monolayer of phospholipids and proteins. LD …
a neutral lipid core surrounded by a monolayer of phospholipids and proteins. LD …
Dynamics and functions of lipid droplets
JA Olzmann, P Carvalho - Nature reviews Molecular cell biology, 2019 - nature.com
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis
C Sztalryd, DL Brasaemle - Biochimica et biophysica acta (bba)-molecular …, 2017 - Elsevier
Lipid droplets in chordates are decorated by two or more members of the perilipin family of
lipid droplet surface proteins. The perilipins sequester lipids by protecting lipid droplets from …
lipid droplet surface proteins. The perilipins sequester lipids by protecting lipid droplets from …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Mechanism and determinants of amphipathic helix-containing protein targeting to lipid droplets
Cytosolic lipid droplets (LDs) are the main storage organelles for metabolic energy in most
cells. They are unusual organelles that are bounded by a phospholipid monolayer and …
cells. They are unusual organelles that are bounded by a phospholipid monolayer and …
Pragmatic coarse-graining of proteins: models and applications
The molecular details involved in the folding, dynamics, organization, and interaction of
proteins with other molecules are often difficult to assess by experimental techniques …
proteins with other molecules are often difficult to assess by experimental techniques …
The many faces of amphipathic helices
Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their
structure and by the segregation of hydrophobic and polar residues between two faces of …
structure and by the segregation of hydrophobic and polar residues between two faces of …
Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome
Lipid droplets (LDs) are reservoirs for triglycerides (TGs) and sterol-esters (SEs), but how
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
Perilipins at a glance
Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy
metabolism, membrane synthesis and production of lipid-derived signaling molecules. While …
metabolism, membrane synthesis and production of lipid-derived signaling molecules. While …