The central nervous system responds to diverse neurologic injuries with a vigorous
activation of astrocytes. While this phenomenon is found in many different species, its …

Neurogenesis persists in the adult dentate gyrus of rodents throughout the life of the
organism. The factors regulating proliferation, survival, migration, and differentiation of …

It has been established that the adult mouse forebrain contains multipotential
(neuronal/glial) progenitor cells that can be induced to proliferate in vitro when epidermal …

Astrocytes are critically important for neuronal circuit assembly and function. Mammalian
protoplasmic astrocytes develop a dense ramified meshwork of cellular processes to form …

In cultures of embryonic and adult mouse striatum, we previously demonstrated that EGF
induces the proliferation of putative stem cells, which give rise to spheres of undifferentiated …

Transforming growth factor-beta 1 (TGF-beta 1) has been shown to up-regulate the
synthesis of nerve growth factor (NGF) in cultured rat astrocytes and in neonatal brain in vivo …

Primary embryonic hippocampal neurons can develop morphologically and functionally in
culture but do not survive more than a few weeks. It has been reported that basic fibroblast …

New evidence indicates that neural activity regulates the expression of trophic factors in the
brain but regulation of these molecules by select aspects of behaviour remains solely a …

Clinical and experimental evidence indicate that physical activity has a positive impact on
brain function; however, the molecular bases for how exercise affects the structure and …

Restrictions in neuronal fate occur during the transition from a multipotential to a postmitotic
cell. This and later steps in neuronal differentiation are determined by extracellular signals …