Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …

Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Neuroinflammation, which involves microglial activation, is thought to play a key role in the
development and progression of neurodegenerative diseases and other brain pathologies …

Neuroinflammation is an adaptive response of the central nervous system to diverse
potentially injurious stimuli, which is closely associated with neurodegeneration and …

Purinergic receptors play important roles in central nervous system (CNS). These receptors
are involved in cellular neuroinflammatory responses that regulate functions of neurons …

Abstract Purpose The P2X7 receptor (P2X7R) is an ATP-gated ion channel predominantly
expressed on activated microglia and is important in neurodegenerative diseases including …

The P2X7 receptor (P2X7R) is an adenosine triphosphate–gated ion channel that is
predominantly expressed on microglial cells in the central nervous system. We report the …

Purpose The novel PET tracer [11 C] SMW139 binds with high affinity to the P2X 7 receptor,
which is expressed on pro-inflammatory microglia. The purposes of this first in-man study …