Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and
progressive disease with high mortality and limited therapeutic options. Excessive …

The platelet‑derived growth factor (PDFG) signaling pathway exerts persistent activation in
response to a variety of stimuli and facilitates the progression of hepatic fibrosis. Since this …

Fibrosis and scar formation results from chronic progressive injury in virtually every tissue
and affects a growing number of people around the world. Myofibroblasts drive fibrosis, and …

Background The novel sodium-glucose co-transporter 2 inhibitor (SGLT2i) potentially
ameliorates heart failure and reduces cardiac arrhythmia. Cardiac fibrosis plays a pivotal …

Inflammation is a characteristic marker in numerous lung disorders. Several immune cells,
such as macrophages, dendritic cells, eosinophils, as well as T and B lymphocytes …

Fibrosis is often the end result of chronic inflammation. It is characterized by the excessive
deposition of extracellular matrix. This leads to structural alterations in the tissue, causing …

We have shown that calcium (Ca2+) oscillations in human pulmonary fibroblasts (HPFs)
contribute to profibrotic effects of transforming growth factor-β (TGF-β) and that disruption of …

Metabolic pathways drive cellular behavior. Severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection causes lung tissue damage directly by targeting cells or indirectly …

The role of Ca2+ signalling in fibroblasts is of great interest in fibrosis‐related diseases.
Intracellular free Ca2+ ([Ca2+] i) is a ubiquitous secondary messenger, regulating a number …