Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel

FN Delling, PA Noseworthy, DH Adams… - Journal of the American …, 2022 - jacc.org
In light of the adverse prognosis related to severe mitral regurgitation, heart failure, or
sudden cardiac death in a subset of patients with mitral valve prolapse (MVP), identifying …

Degenerative mitral regurgitation

V Delgado, N Ajmone Marsan, RO Bonow… - Nature Reviews …, 2023 - nature.com
Degenerative mitral regurgitation is a major threat to public health and affects at least 24
million people worldwide, with an estimated 0.88 million disability-adjusted life years and …

Genetics and pathophysiology of mitral valve prolapse

C Delwarde, R Capoulade, J Mérot… - Frontiers in …, 2023 - frontiersin.org
Mitral valve prolapse (MVP) is a common condition affecting 2–3% of the general
population, and the most complex form of valve pathology, with a complication rate up to 10 …

Abnormal mechanics relate to myocardial fibrosis and ventricular arrhythmias in patients with mitral valve prolapse

Y Nagata, PB Bertrand, V Baliyan… - Circulation …, 2023 - Am Heart Assoc
Background: The relation between ventricular arrhythmia and fibrosis in mitral valve
prolapse (MVP) is reported, but underlying valve-induced mechanisms remain unknown. We …

Imaging for the assessment of the arrhythmogenic potential of mitral valve prolapse

A Esposito, M Gatti, MG Trivieri, E Agricola, G Peretto… - European …, 2024 - Springer
Mitral valve prolapse (MVP) is the most common valve disease in the western world and
recently emerged as a possible substrate for sudden cardiac death (SCD). It is estimated an …

Mitral annular disjunction in the context of mitral valve prolapse: identifying the at-risk patient

P Van der Bijl, J Stassen, KH Haugaa, B Essayagh… - Cardiovascular …, 2024 - jacc.org
Mitral annular disjunction (MAD), a separation between the left atrium/mitral valve annulus
and the left ventricular myocardium, is frequently seen in patients with arrhythmic mitral …

Native and post-repair residual mitral valve prolapse increases forces exerted on the papillary muscles: a possible mechanism for localized fibrosis?

MH Park, A van Kampen, S Melnitchouk… - Circulation …, 2022 - Am Heart Assoc
Background: Recent studies have linked mitral valve prolapse to localized myocardial
fibrosis, ventricular arrhythmia, and even sudden cardiac death independent of mitral …

[HTML][HTML] Mitral annulus disjunction in consecutive patients undergoing cardiovascular magnetic resonance: Where is the boundary between normality and disease?

S Figliozzi, K Stankowski, L Tondi, F Catapano… - Journal of …, 2024 - Elsevier
Background The presence of mitral annulus disjunction (MAD) has been considered a high-
risk feature for sudden cardiac death based on selected study populations. We aimed to …

Left ventricular remodeling in non-syndromic mitral valve prolapse: volume overload or concomitant cardiomyopathy?

LL Pype, PB Bertrand, BP Paelinck… - Frontiers in …, 2022 - frontiersin.org
Mitral valve prolapse (MVP) is a common valvular disorder that can be associated with mitral
regurgitation (MR), heart failure, ventricular arrhythmias and sudden cardiac death. Given …

[HTML][HTML] Arrhythmogenic mitral valve prolapse and sudden cardiac death: an update and current perspectives

V Battaglia, G Santangelo, F Bursi, P Simeoli… - Current Problems in …, 2023 - Elsevier
Mitral valve prolapse (MVP) affects about 2% to 3% of the general population, mostly
women, and is the most common cause of primary chronic mitral regurgitation (MR) in …