The tuberculosis (TB) epidemic is most prevalent in the elderly, and there is a progressive
increase in the notification rate with age. Most cases of TB in the elderly are linked to the …

Forming the first line of defence against virally infected and malignant cells, natural killer
(NK) cells are critical effector cells of the innate immune system. With age, significant …

Objectives To describe clinical characteristics, management and outcome of individuals with
coronavirus disease 2019 (COVID-19); and to evaluate risk factors for all-cause in-hospital …

Rationale: In patients with community-acquired pneumonia, guidelines recommend
antibiotic treatment for 7 to 21 d. Procalcitonin is elevated in bacterial infections, and its …

Abstract Background Pneumococcal conjugate vaccines (PCVs) have greatly reduced the
incidence of pneumococcal disease, yet unmet medical need remains due to increased …

Background Community-acquired pneumonia (CAP) is the most frequent infection-related
cause of death. The reference standard to diagnose CAP is a new infiltrate on chest …

Poor oral health and hygiene are increasingly recognized as major risk factors for
pneumonia among the elderly. To identify modifiable oral health–related risk factors, we …

Recent studies suggest that activation of the peripheral immune system elicits a discordant
central (ie, in the brain) inflammatory response in aged but otherwise healthy subjects …

Acute cognitive disorders are common in elderly patients with peripheral infections but it is
not clear why. Here, we injected old and young mice with Escherichia coli …

Objective To determine the efficacy of a 23-valent pneumococcal polysaccharide vaccine in
people at high risk of pneumococcal pneumonia. Design Prospective, randomised, placebo …