Executive summary Every infant, child, and adolescent will experience pain at times
throughout their life. Childhood pain ranges from acute to chronic, and includes procedural …

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

Background: The management of acute and chronic pain for individuals living with sickle cell
disease (SCD) is a clinical challenge. This reflects the paucity of clinical SCD pain research …

In July 2022, these guidelines were reviewed by an expert work group convened by ASH.
Review included limited searches for new evidence and discussion of the search results …

Background: Central nervous system (CNS) complications are among the most common,
devastating sequelae of sickle cell disease (SCD) occurring throughout the lifespan …

Despite advances in supportive therapy to prevent complications of sickle cell disease
(SCD), access to care is not universal. Hematopoietic cell transplantation is, to date, the only …

Two decades of epidemiological research shows that silent cerebrovascular disease is
common and is associated with future risk for stroke and dementia. It is the most common …

Background For children with sickle cell anaemia and high transcranial doppler (TCD) flow
velocities, regular blood transfusions can effectively prevent primary stroke, but must be …

Background Hydroxyurea is an effective treatment for sickle cell anemia, but few studies
have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting …

Sickle cell disease (SCD) is a hereditary blood disorder characterized by the production of
abnormal hemoglobin molecules that cause red blood cells to take on a crescent or sickle …