The term B-factor, sometimes called the Debye–Waller factor, temperature factor, or atomic
displacement parameter, is used in protein crystallography to describe the attenuation of X …

Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze
the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building …

The computational study of enantioselective reactions is a challenging task that requires
high accuracy, as very small energy differences have to be reproduced. Quantum chemical …

Diaryl ketones are important building blocks for synthesizing pharmaceuticals and are
generally regarded as “difficult-to-reduce” ketones due to the large steric hindrance of their …

Unspecific peroxygenases (UPOs) perform oxyfunctionalizations for a wide range of
substrates utilizing H2O2 without the need for further reductive equivalents or electron …

The FRISM strategy has emerged as one of the most efficient methods for protein
engineering. It involves the identification of hotspots, which is usually rationalized through …

Regioselective hydroxylations of aromatic compounds are useful reactions but often lack
appropriate catalysts. Here a group of P450BM3 mutants (R47I/A82F/A328F …

l-Threonine aldolase (LTA) is an attractive tool in organic chemistry for catalyzing the
formation of β-hydroxy-α-amino acids with two chiral centers. The enzyme has a strict …

Due to its stringent stereospecificity, D‐amino acid oxidase (DAAO) has made it very easy to
synthesize L‐amino acids. However, the low activity of the wild‐type enzyme toward …

Unspecific peroxygenases (UPOs) enable oxyfunctionalizations of a broad substrate range
with unparalleled activities. Tailoring these enzymes for chemo-and regioselective …