Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

Cochlear implantation has become the standard‐of‐care for adults and children with severe
to profound hearing loss. There is growing evidence that qualitative as well as quantitative …

Motivation: Homology models of proteins are of great interest for planning and analysing
biological experiments when no experimental three-dimensional structures are available …

The highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) poses a
constant threat to human health. The viral spike protein (SARS-S) mediates host cell entry …

Large collections of knockout organisms facilitate the elucidation of gene functions. Here we
used retroviral insertion or homologous recombination to disrupt 472 genes encoding …

Tight junctions in the cochlear duct are thought to compartmentalize endolymph and provide
structural support for the auditory neuroepithelium. The claudin family of genes is known to …

Spinocerebellar ataxia type 31 (SCA31) is an adult-onset autosomal-dominant
neurodegenerative disorder showing progressive cerebellar ataxia mainly affecting Purkinje …

Gene regulatory changes are thought to be major factors driving species evolution, with
creation of new regulatory regions likely being instrumental in contributing to diversity …

▪ Abstract Hereditary isolated hearing loss is genetically highly heterogeneous. Over 100
genes are predicted to cause this disorder in humans. Sixty loci have been reported and 24 …

Matriptase/MT-SP1 is a novel tumor-associated type II transmembrane serine protease that
is highly expressed in the epidermis, thymic stroma, and other epithelia. A null mutation was …