The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has
been a versatile field of study for a long time for its diverse biological and medicinal …

As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

As of December 2022, there have been over 642 million confirmed cases of COVID-19 (10).
The pandemic has thus far claimed approximately 6.62 million lives (10). Vaccination is …

Updates This is the fourteenth version (thirteenth update) of the living guideline, replacing
earlier versions (available as data supplements). New recommendations will be published …

The evidence base for therapeutics for covid-19 is evolving with numerous randomised
controlled trials (RCTs) recently completed and under way. This update adds new …

Remdesivir 1 is an phosphoramidate prodrug that releases the monophosphate of
nucleoside GS-441524 (2) into lung cells, thereby forming the bioactive triphosphate 2-NTP …

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), remains a global public health crisis. The reduced efficacy of therapeutic …

Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of a
1′-cyano-4-aza-7, 9-dideazaadenosine C-nucleoside (GS-441524) that is FDA approved …

GS‐441524, the parent nucleoside of remdesivir, has been proposed to be effective against
Covid‐19 based on in vitro studies and studies in animals. However, randomized clinical …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and related variants, are
responsible for the devastating coronavirus disease 2019 (COVID-19) pandemic. The SARS …