Methods to functionalize arenes and heteroarenes in a site-selective manner are highly
sought after for rapidly constructing value-added molecules of medicinal, agrochemical, and …

This Review examines parts per million (ppm) palladium concentrations in catalytic cross-
coupling reactions and their relationship with mole percentage (mol%). Most studies in …

Allosteric receptor modulation is an attractive concept in drug targeting because it offers
important potential advantages over conventional orthosteric agonism or antagonism …

A novel series of 4-[4-(6-phenyl-pyrimidin-4-yl)-phenoxymethyl]-chromen-2-ones [5–7 (a–e)]
were synthesized from various 4-bromomethyl coumarins 1 (a–e). The synthesized …

This study was designed to determine the effectiveness of 5-(3-Hydroxybenzylidene)-2, 4, 6
(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6 (1H, 3H, 5H) …

The calcium-sensing receptor (CaR) belongs to the G protein-coupled receptor superfamily,
with a characteristic structure consisting of seven transmembrane helices, an intracellular C …

Three types of morphologically and functionally distinct taste cells operate in the mammalian
taste bud. We demonstrate here the expression of two G-protein-coupled receptors from the …

Pleiotropic intervention may be a requirement for effective limitation of the progression of
multifactorial diseases such as Alzheimer's Disease. One approach to such intervention is to …

Published data on the main approaches to the formation of the heterocyclic 2-
aminopyrimidine system, which is one of important pharmacophores responsible for the …

The extracellular calcium receptor (CaR) is a G protein-coupled receptor (GPCR) and the
pivotal molecule regulating systemic Ca 2+ homeostasis. The CaR was a challenging target …