Lung cancer is the leading cause of cancer death in the United States and around the world.
Almost as many Americans die of lung cancer every year than die of prostate, breast, and …

Although cytosolic glutathione S-transferase (GST) enzymes occupy a key position in
biological detoxification processes, two of the most relevant human isoenzymes, GSTT1-1 …

Purpose Lung cancer is a leading cause of cancer death worldwide. Although smoking
remains the predominant cause of lung cancer, lung cancer in never smokers is an …

PURPOSE Approximately 10%-40% of patients with lung cancer report no history of tobacco
smoking (never-smokers). We analyzed whole-exome and RNA-sequencing data of 160 …

The majority of lung cancers are caused by long term exposure to the several classes of
carcinogens present in tobacco smoke. Although a significant fraction of lung cancers in …

Multiple genes have been studied for potential associations with lung cancer. The gene
most frequently associated with increased risk has been glutathione S-transferase M1 …

Background Glutathione S-transferases (GSTs) are known to abolish or reduce the activities
of intracellular enzymes that help detoxify environmental carcinogens, such as those found …

The cytochrome P450 (CYP) superfamily of enzymes catalyse one of the first steps in the
metabolism of carcinogens such as polycyclic aromatic hydrocarbons, nitroaromatics and …

Lung cancer is the leading cause of cancer-related death in both men and women.
Environmental carcinogens, particularly tobacco smoke, play a dominant role in the …

Lung cancer is the most common malignancy in the Western world, and the main risk factor
is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated …