Objective The aim of this article is to discuss mutant p53 as a possible therapeutic target and
biomarker for breast cancer. Results TP53 (p53) is the most frequently mutated gene in …

The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …

The proteome provides unique insights into disease biology beyond the genome and
transcriptome. A lack of large proteomic datasets has restricted the identification of new …

Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they
tend to actively proliferate more than normal cells. They have well-known side-effects …

Natural products have been studied to reveal new therapies against human dysfunctions
since they present several medicinal properties. Caffeine, theobromine and (+)-catechin are …

The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …

Sažetak One of the most important factors involved in the response to oxidative stress (OS)
is the nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of …

MicroRNAs are post-transcriptional mediators of gene expression and regulation, which play
influential roles in tumorigenesis and cancer metastasis. The expression of tumor …

The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-
function (GOF) activities that affect molecular pathways crucial for tumorigenesis and …

The ubiquitination pathway and proteasomal degradation machinery dominantly regulate
p53 tumor suppressor protein stability, localization, and functions in both normal and …