Mutant p53 in breast cancer: potential as a therapeutic target and biomarker
MJ Duffy, NC Synnott, J Crown - Breast cancer research and treatment, 2018 - Springer
Objective The aim of this article is to discuss mutant p53 as a possible therapeutic target and
biomarker for breast cancer. Results TP53 (p53) is the most frequently mutated gene in …
biomarker for breast cancer. Results TP53 (p53) is the most frequently mutated gene in …
[HTML][HTML] New therapeutic strategies to treat human cancers expressing mutant p53 proteins
G Blandino, S Di Agostino - Journal of Experimental & Clinical Cancer …, 2018 - Springer
The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …
[HTML][HTML] Pan-cancer proteomic map of 949 human cell lines
The proteome provides unique insights into disease biology beyond the genome and
transcriptome. A lack of large proteomic datasets has restricted the identification of new …
transcriptome. A lack of large proteomic datasets has restricted the identification of new …
[HTML][HTML] Pharmacological targeting of cell cycle, apoptotic and cell adhesion signaling pathways implicated in chemoresistance of cancer cells
Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they
tend to actively proliferate more than normal cells. They have well-known side-effects …
tend to actively proliferate more than normal cells. They have well-known side-effects …
Natural products targeting into cancer hallmarks: An update on caffeine, theobromine, and (+)-catechin
FC Cadoná, RF Dantas, GH de Mello… - Critical Reviews in …, 2022 - Taylor & Francis
Natural products have been studied to reveal new therapies against human dysfunctions
since they present several medicinal properties. Caffeine, theobromine and (+)-catechin are …
since they present several medicinal properties. Caffeine, theobromine and (+)-catechin are …
[HTML][HTML] Cancer stemness: p53 at the wheel
D Ghatak, D Das Ghosh, S Roychoudhury - Frontiers in oncology, 2021 - frontiersin.org
The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …
differentiation to sustain a limited repertoire of stem cells for proper development and …
[HTML][HTML] The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer
L Xia, W Ma, A Afrashteh, MA Sajadi, H Fakheri… - Biochemia …, 2023 - hrcak.srce.hr
Sažetak One of the most important factors involved in the response to oxidative stress (OS)
is the nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of …
is the nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of …
[HTML][HTML] Regulatory mechanisms of miR-145 expression and the importance of its function in cancer metastasis
MicroRNAs are post-transcriptional mediators of gene expression and regulation, which play
influential roles in tumorigenesis and cancer metastasis. The expression of tumor …
influential roles in tumorigenesis and cancer metastasis. The expression of tumor …
[HTML][HTML] Transition of amyloid/mutant p53 from tumor suppressor to an oncogene and therapeutic approaches to ameliorate metastasis and cancer stemness
The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-
function (GOF) activities that affect molecular pathways crucial for tumorigenesis and …
function (GOF) activities that affect molecular pathways crucial for tumorigenesis and …
[HTML][HTML] Essential roles of E3 ubiquitin ligases in p53 regulation
S Sane, K Rezvani - International journal of molecular sciences, 2017 - mdpi.com
The ubiquitination pathway and proteasomal degradation machinery dominantly regulate
p53 tumor suppressor protein stability, localization, and functions in both normal and …
p53 tumor suppressor protein stability, localization, and functions in both normal and …