Aging is a natural process that determined by a functional decline in cells and tissues as
organisms are growing old, resulting in an increase at risk of disease and death. To this end …

Reactive oxygen species (ROS) can be beneficial or harmful in health and disease. While
low levels of ROS serve as signaling molecules to regulate vascular tone and the growth …

Preventing islet β‐cells death is crucial for treating type 2 diabetes mellitus (T2DM).
Currently, clinical drugs are being developed to improve the quality of T2DM care and self …

Vascular diseases, such as peripheral artery disease (PAD), are associated with diabetes
mellitus and a higher risk of cardiovascular disease and even death. Surgical …

Diabetes mellitus may cause severe damage to retinal blood vessels. The central aim of this
study was to test the hypothesis that sulodexide, a mixture of glycosaminoglycans, has a …

Long term consequences of diabetes mellitus (DM) may include multi-organ complications
such as retinopathy, cardiovascular disease, neuronal, and kidney damage. One of the most …

Background Reports have implicated diabetes mellitus (DM) and Alzheimer's disease (AD)
as some of the global persistent health challenges with no lasting solutions, despite of …

α‐Ketoglutarate (α‐KG) is a metabolite in the tricarboxylic acid cycle. It has a strong
antioxidant function and can effectively prevent oxidative damage. Previous studies have …

Objective This study investigated the actions of advanced glycated end‐products (AGE),
their receptors (RAGE), and NAD (P) H oxidase (Nox) subtypes 1, 2, and 4 on mechanisms …

Oxidative stress plays a pivotal role in the pathogenesis and progression of cardiovascular
diseases (CVDs). This review focuses on the signaling pathways of oxidative stress during …