Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …
Controlling the size of lipid droplets: lipid and protein factors
Recent advances have transformed our understanding of lipid droplets (LDs). Once
regarded as inert lipid storage granules, LDs are now recognized as multi-functional …
regarded as inert lipid storage granules, LDs are now recognized as multi-functional …
Arabidopsis SEIPIN proteins modulate triacylglycerol accumulation and influence lipid droplet proliferation
The lipodystrophy protein SEIPIN is important for lipid droplet (LD) biogenesis in human and
yeast cells. In contrast with the single SEIPIN genes in humans and yeast, there are three …
yeast cells. In contrast with the single SEIPIN genes in humans and yeast, there are three …
Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16
CW Wang, YH Miao, YS Chang - Journal of cell science, 2014 - journals.biologists.com
The human congenital generalized lipodystrophy type 2 protein seipin (Fld1 in budding
yeast) controls lipid droplet (LD) size through an unknown mechanism. Here, we report that …
yeast) controls lipid droplet (LD) size through an unknown mechanism. Here, we report that …
[HTML][HTML] Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring
M Dahlhoff, S Pfister, A Blutke, J Rozman… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Vulnerability of the fetus upon maternal obesity can potentially occur during all
developmental phases. We aimed at elaborating longer-term health outcomes of fetal …
developmental phases. We aimed at elaborating longer-term health outcomes of fetal …
Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation
B Renvoisé, B Malone, M Falgairolle… - Human molecular …, 2016 - academic.oup.com
Hereditary spastic paraplegias (HSPs; SPG1-76 plus others) are length-dependent
disorders affecting long corticospinal axons, and the most common autosomal dominant …
disorders affecting long corticospinal axons, and the most common autosomal dominant …
Adipose-Specific Knockout of Seipin/Bscl2 Results in Progressive Lipodystrophy
Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is the most severe form of human
lipodystrophy, characterized by an almost complete loss of adipose tissue and severe …
lipodystrophy, characterized by an almost complete loss of adipose tissue and severe …
[HTML][HTML] Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis
MMU Talukder, MFM Sim, S O'Rahilly… - Molecular …, 2015 - Elsevier
Objective Disruption of the genes encoding either seipin or 1-acylglycerol-3-phosphate O-
acyltransferase 2 (AGPAT2) causes severe congenital generalized lipodystrophy (CGL) in …
acyltransferase 2 (AGPAT2) causes severe congenital generalized lipodystrophy (CGL) in …
[HTML][HTML] The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1
MFM Sim, RJ Dennis, EM Aubry, N Ramanathan… - Molecular …, 2013 - Elsevier
Disruption of the gene BSCL2 causes a severe, generalised lipodystrophy, demonstrating
the critical role of its protein product, seipin, in human adipose tissue development. Seipin is …
the critical role of its protein product, seipin, in human adipose tissue development. Seipin is …
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development [S]
The expansion of lipid droplets (LDs) and the differentiation of preadipocytes are two
important aspects of mammalian lipid storage. In this study, we examined the role of CDP …
important aspects of mammalian lipid storage. In this study, we examined the role of CDP …