Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …

Importance Deficiency of adenosine deaminase 2 (DADA2) is a recessively inherited
disease characterized by systemic vasculitis, early-onset stroke, bone marrow failure, and/or …

Deficiency of adenosine deaminase 2 (DADA2) was first described as a monogenic form of
systemic vasculitis that closely resembles polyarteritis nodosa (PAN). The phenotypic …

Deficiency of adenosine deaminase type 2 (DADA2) was first described in 2014 as a
monogenic cause of polyartertitis nodosa (PAN), early onset lacunar stroke and livedo …

Objective Adenosine deaminase (ADA) plays an important role in immune response, which
includes two isoenzymes: ADA1 and ADA2. This study aims to explore the roles of ADA1 …

Deficiency of adenosine deaminase 2 (DADA2) is an inherited autosomal recessive disease
characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa …

Identifying genetic variation underlying human diseases establishes targets for therapeutic
development and helps tailor treatments to individual patients. Large-scale transcriptomic …

Dendritic cells (DCs) are crucial cells for initiating and maintaining immune response. They
play critical role in homeostasis, inflammation, and autoimmunity. A number of molecules …

Purpose Persistent human papillomavirus infection (PHPVI) causes cutaneous, anogenital,
and mucosal warts. Cutaneous warts include common warts, Treeman syndrome, and …

Deficiency of Adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disorder
presenting with a broad spectrum of clinical manifestations, including immunodeficiency …