Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and
degradation. Excessive ECM deposition results in scarring and thickening of the affected …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the intricate alveolar network of
the lung is progressively replaced by fibrotic scars. Myofibroblasts are the effector cells that …

Matrix stiffening with downstream activation of mechanosensitive pathways is strongly
implicated in progressive fibrosis; however, pathologic changes in extracellular matrix …

Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …

Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are
able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) …

Despite progress in use of decellularized lung scaffolds in ex vivo lung bioengineering
schemes, including use of gels and other materials derived from the scaffolds, the detailed …

The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate
(DS) generates biological information that can be unique to each of these …

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology;
however, apoptosis of lung alveolar epithelial cells plays a role in disease progression. This …