Reactive oxygen species mediated apoptotic death of colon cancer cells: Therapeutic potential of plant derived alkaloids

VK Nelson, MV Nuli, J Mastanaiah… - Frontiers in …, 2023 - frontiersin.org
Colorectal cancer (CRC) is one of the most deaths causing diseases worldwide. Several risk
factors including hormones like insulin and insulin like growth factors (eg, IGF-1) have been …

Natural products as the modulators of oxidative stress: an herbal approach in the management of prostate cancer

VK Nelson, CP Pullaiah, M Saleem TS… - Oxidative Stress and …, 2022 - Springer
Prostate cancer is the most commonly diagnosed and frequently occurred cancer in the
males globally. The current treatment strategies available to treat prostate cancer are not …

IL-13 and the hydroperoxy fatty acid 13 (S) HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis

P Biswas, S Swaroop, N Dutta, A Arya, S Ghosh… - Free Radical Biology …, 2023 - Elsevier
This study depicted the effect of IL-13 and 13 (S) HpODE (the endogenous product during IL-
13 activation) in the process of cancer cell apoptosis. We examined the role of both IL-13 …

The molecular mechanism for inhibiting the growth of nasopharyngeal carcinoma cells using polymethoxyflavonoids purified from pericarp of Citrus reticulata 'Chachi' …

W Yang, Y Liang, Y Liu, B Chen, K Wang… - Frontiers in …, 2023 - frontiersin.org
Polymethoxyflavonoids (PMFs), the main bioactive compounds naturally occurring in the
pericarp of Citrus reticulata 'Chachi'(CRCP), possess significant antitumor action. However …

Autophagy regulates apoptosis of colorectal cancer cells based on signaling pathways

Y Yan, W Yu, M Guo, N Zhu, X Chen, N Li, C Zhong… - Discover Oncology, 2024 - Springer
Colorectal cancer is a common malignant tumor of the digestive system. Its morbidity and
mortality rank among the highest in the world. Cancer development is associated with …

Tinospora sinensis (Lour.) Merr alkaloid rich extract induces colon cancer cell death via ROS mediated, mTOR dependent apoptosis pathway: “an in-vitro study”

S Badavenkatappa gari, VK Nelson… - … Medicine and Therapies, 2023 - Springer
Background Colorectal cancer (CRC) is the second most mortality rate causing disease after
lung cancer. Though there is a significant improvement in the treatment schedule offered to …

Anticancer effect of polyphenolic acid enriched fractions from Grewia bracteata Roth on tumor cells and their p53 gene independent ROS mediated apoptosis in colon …

MAA Abdelaziz, VK Nelson, M Kumarasamy… - Toxicon, 2023 - Elsevier
It is the first report on leaves of Grewia bracteata Roth for its anticancer effect. In this study,
three polarity-guided solvent extracts of Grewia bracteata leaves from n-hexane (GLH), ethyl …

Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging

N Dutta, JA Gerke, SF Odron, JD Morris, A Hruby, J Kim… - GeroScience, 2024 - Springer
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant
promise to provide valuable insights to the field of mitochondrial research and aging biology …

[HTML][HTML] Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging

N Dutta, JA Gerke, SF Odron, JD Morris, A Hruby… - Biorxiv, 2023 - ncbi.nlm.nih.gov
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant
promise to provide valuable insights to the field of mitochondrial research and aging biology …

Review on the Pharmacognostical, Phytochemical and Pharmacological aspects of Tabernaemontana coronaria.

K SEKAR, RV BHARATHI… - Indian Journal of …, 2024 - search.ebscohost.com
Tabernaemontana coronaria is an ornamental, evergreen, dichotomously branched shrub or
small tree with large, shiny dark green leaves and white coloured flowers, pinwheel …