Research in the field of transfer RNA (tRNA) has undergone revolutionary changes in the
past few years. Although there has been a steady accumulation of chemical and biological …

Onpattro, the first RNAi-based therapeutic to receive FDA approval, is enabled by a lipid
nanoparticle (LNP) system that facilitates siRNA delivery into the cytoplasm of target cells …

Previous work has shown that lipid nanoparticles (LNP) composed of an ionizable cationic
lipid, a poly (ethylene glycol)(PEG) lipid, distearoylphosphatidylcholine (DSPC), cholesterol …

We describe Curves+, a new nucleic acid conformational analysis program which is
applicable to a wide range of nucleic acid structures, including those with up to four strands …

Lipid nanoparticles (LNP) containing ionizable cationic lipids are the leading systems for
enabling therapeutic applications of siRNA; however, the structure of these systems has not …

The algorithm “Curves”, that we have recently presented in this journal (J. Biolmol. Str.
Dynam. 6, 63–91 (1988)), is updated to take into account the conventions developed at the …

In this article, we have described various detailed features of the conformation of yeast
tRNAPhe revealed by recent refinement analysis of x-ray diffraction data at 2.5 A resolution …

Structural polymorphism of DNA has been studied for nearly thirty years by means of fibre
diffraction techniques (Watson and Crick, 1953; Langridge et al., 1960; Arnott, 1976; Leslie …

An algorithm is presented which solves the problem of obtaining a rigorous helicoidal
description of an irregular nucleic acid segment. Central to this approach is the definition of …

Curves+, a revised version of the Curves software for analyzing the conformation of nucleic
acid structures, is now available as a web server. This version, which can be freely accessed …