Microorganisms have been extensively applied as active biotherapeutic agents or drug
delivery vehicles for antitumor treatment because of their unparalleled bio-functionalities …

Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when
combined, make them ideally suited for cellular-based immunotherapy and as vehicles for …

Human adipose tissue–derived mesenchymal stem cells (AT-MSC) are considered to be a
promising source of autologous stem cells in personalized cell-based therapies. Tumor …

The primary study objective was to determine the safety of intraprostatic administration of a
replication-competent, oncolytic adenovirus containing a cytosine deaminase (CD)/herpes …

The principle of using suicide genes for gene directed enzyme prodrug therapy (GDEPT) of
cancer has gained increasing significance during the 20 years since its inception. The astute …

Background Previously, we validated capability of human adipose tissue‐derived
mesenchymal stem cells (AT‐MSC) to serve as cellular vehicles for gene‐directed enzyme …

Patients with the most common and aggressive form of high-grade glioma, glioblastoma
multiforme, have poor prognosis and few treatment options. In 2 immunocompetent mouse …

There is no effective treatment for late stage and metastatic cancers of colorectal, prostate,
pancreatic, breast, glioblastoma and melanoma cancers. Novel treatment modalities are …

Suicide gene therapy mediated by mesenchymal stem cells with their ability to engraft into
tumors makes these therapeutic stem cells an attractive tool to activate prodrugs directly …

A long-held central dogma of radiation biology has been that the carcinogenic effects of
ionizing radiation (IR) are induced by the direct and radiolytic actions of IR on nuclear DNA …