Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with
tissue injury and necrosis. The disease can be mild, involving only the pancreas, and …

Acute pancreatitis (AP) is an inflammatory disease that can progress to severe acute
pancreatitis (SAP), which increases the risk of death. AP is characterized by inappropriate …

Recent studies have highlighted the importance of autophagy and particularly non-
canonical autophagy in the development and progression of acute pancreatitis (a frequent …

Autophagy is an evolutionarily conserved process that degrades damaged organelles and
recycles macromolecules to support cell survival. However, in certain disease states …

Pancreatic acinar cells require high rates of amino acid uptake for digestive enzyme
synthesis, but excessive concentrations can trigger acute pancreatitis (AP) by mechanisms …

Acute pancreatitis (AP) is a common abdominal disease that typically resolves on its own,
but the mortality rate dramatically increases when it progresses to severe acute pancreatitis …

Acute pancreatitis is a severe inflammatory disorder with limited treatment options. Improved
understanding of disease mechanisms has led to new and potential therapies. Here we …

Acute pancreatitis is a frequent disease that lacks specific drug treatment. Unravelling the
molecular mechanisms of acute pancreatitis is essential for the development of new …