Drug delivery systems (DDS) triggered by local microenvironment represents the state-of-art
of nanomedicine design, where the triggering hallmarks at intracellular and subcellular …

In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …

Thrombotic cerebro-cardiovascular diseases are the leading causes of disability and death
worldwide. However, current drug therapeutics are compromised by narrow therapeutic …

The regulation of tumor immunosuppressive microenvironments via precise drug delivery is
a promising strategy for preventing tumor recurrence and metastasis. Inspired by the stealth …

Bone metastasis is the main cause of death in patients with prostate cancer (PCa), but there
lacks effective treatment method. Immunotherapy shows new hopes for bone metastatic PCa …

Since the inception of the concept of “magic bullet”, nanoparticles have evolved to be one of
the most effective carriers in drug delivery. Nanoparticles improve the therapeutic efficacy of …

Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

Inflammatory responses, manifested in excessive oxidative stress and microglia
overactivation, together with metal ion-triggered amyloid-beta (Aβ) deposition, are critical …

The diagnosis of brain metastasis (BrM) has historically been a dooming diagnosis that is
nothing less than a death sentence, with few treatment options for palliation or prolonging …

Despite the great progress of current bacterially based biotherapeutics, their unsatisfying
efficacy and underlying safety problems have limited their clinical application. Herein …